Research

The Division of Pediatric Critical Care Medicine is active in clinical and basic science research projects and participates in multi-institution clinical studies.
Recently completed studies include:

The addition of aminophylline to conventional diuretics in patients with elevated FK506 levels and renal insufficiency
A randomized, blinded study of infasurf (Calfactant) in acute pediatric respiratory failure

Clinical studies currently underway include:

Head cooling on traumatic brain injury in children
Genomic analysis of acute sepsis in children
Multi-center randomized trial of inhale nitric oxide in pediatric respiratory failure

Dr. McLaughlin is spearheading an initiative to assess development and quality of life outcomes in young solid organ transplant recipients.

Ongoing basic science endeavors in the Critical Care Laboratory at the Batchelor Children's Research Institute include examination of a new pediatric model of ischemic stroke in piglets, central nervous system transplantation of stem cells derived from bone marrow and adipose tissue into piglet brain, cerebral perfusion and quantitative glucose metabolism imaging in a piglet model of pediatric brain injury using hybrid SPECT/PET, the identification of PTP-δ ligand function within specific regions of the extra cellular domain, and a genomic analysis of pediatric SIRS.