Hematology/Oncology Research

Hematology/Oncology Research

The Pediatric Hematology-Oncology Program is actively engaged in both basic science and clinical research. It is our mission to take novel techniques developed in our basic science laboratories as well as those developed around the world, and create new treatment options for patients.

As members of the Sylvester Comprehensive Cancer Center (SCCC) our pediatric oncologists collaborate with more than 250 physicians and scientists dedicated to cancer care and research. Sylvester opened in 1992 to provide comprehensive cancer services, and today, serves as the hub for cancer-related research, diagnosis, and treatment at the University of Miami Leonard M. Miller School of Medicine.

Basic Laboratory Research:

Our basic science research effort is led by Julio Barredo, M.D. Dr. Barredo’s work focuses on investigating drug resistance and development of new therapies for childhood leukemia. Dr. Barredo is currently funded by the National Cancer Institute, the Leukemia & Lymphoma Society, the Women’s Cancer Association, the STOP Children’s Cancer Foundation, the Micah Batchelor Award for Excellence in Child Health Research, and others. Dr. Barredo also serves as co-leader of the SCCC Molecular Therapeutics Research Program.

In addition to Dr. Barredo’s laboratory, a second basic research laboratory, led by Samita Andreansky Ph.D., centers on the development of cancer vaccines. Joining the Miller School of Medicine from the University of Arizona, Dr. Andreansky has extensive experience with viral oncology and tumor immunology. Her work is currently funded by the American Cancer Society.

Clinical Research:

The Division of Pediatric Hematology/Oncology participates in clinical trials for pediatric/young adult cancers and blood disorders. The Early Phase Clinical Trials Program brings experimental agents to pediatric/young adult oncology patients in the state of Florida in a collaborative method of care.

Leukemias & Lymphomas
We are a full member of Therapeutic Advances in Childhood Leukemia and Lymphoma. As a TACL member, phase I/II trials are available through our group, and dovetail with very high risk leukemia patients who are under consideration for hematopoietic stem cell transplant through our designated Children’s Oncology Group Bone Marrow Transplant institute.

Sarcomas & Brain Tumors
We have a major focus on developing tumor vaccines for solid tumors and brain tumors of childhood, as well as clinical trials for adolescent and young adult patients. As member of Sarcoma Alliance for Research through Collaboration, we have the opportunity to bring clinical trials for sarcomas to patients in south Florida.

Through our involvement in national groups, we are able to develop and lead clinical trials for children across the country based on the work of our own laboratory investigators. Currently there are 12 open pediatric Phase I/II protocols for childhood leukemia and solid tumors. Please click here for a list of clinical trials.

The Sickle Cell Disease Program is funded by the National Heart Lung and Blood Institute and is one of only ten national Basic and Translational Research Programs in Sickle Cell Disease. NIH-sponsored clinical trials in which the Pediatric Sickle Cell Program participate include:

  • SWiTCH (Stroke with Transfusions Changed to Hydroxyurea) for children with sickle cell and stroke
  • TWiTCH (TCD with Transfusions Changed to Hydroxyurea) for children with sickle cell and risk of a future stroke
  • Baby HUG Follow-Up for young children who were treated with hydroxyurea or placebo in Baby HUG Clinical Trial
  • Parent Focused Intervention to Improve Academic Success in Children with Sickle Cell Disease

For additional information regarding our research efforts please contact us at 305-585-5635.