Research : Cardiac Signal Transduction and Cellular Biology Laboratory

Selected Publications

Research Articles

  • Kapiloff, M.S., Farkash, Y., Wegner, M., and Rosenfeld, M.G. Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements. Science, 253: 786-789, 1991.
  • Kapiloff, M.S., Jackson, N., and Airhart, N. mAKAP and the Ryanodine Receptor Are Part of a Multi-Component Signaling Complex on the Cardiomyocyte Nuclear Membrane. Journal of Cell Science, 114: 3167-3176, 2001.
  • Pare, G.C., Easlick, J.L., Mislow, J.M., McNally, E.M., and Kapiloff, M.S. Nesprin-1α Contributes to the Targeting of mAKAP to the Cardiac Myocyte Nuclear Envelope. Experimental Cell Research, 303: 388-399, 2005.
  • Pare, G.C., Bauman, A.L., McHenry, M., Michel, J.J.C., Dodge-Kafka, K.L., and Kapiloff, M.S. The mAKAP Complex Participates In The Induction Of Cardiac Myocyte Hypertrophy by Adrenergic Receptor Signaling. Journal of Cell Science, 118: 5637-5646, 2005.
  • Dodge-Kafka, K.L., Soughayer, J., Pare, G.C., Michel, J.J.C., Langeberg, L.K., Kapiloff, M.S., and Scott, J.D. The Protein Kinase A Anchoring Protein mAKAP Co-ordinates Two cAMP Effector Pathways. Nature, 437: 574-578, 2005. PMC1636584.
  • Michel, J.J.C., Townley, I.K., Dodge-Kafka, K.L., Zhang, F., Kapiloff, M.S., and Scott, J.D. Spatial restriction of PDK1 activation cascades by anchoring to mAKAPα. Molecular Cell, 20: 661-672, 2005.
  • Kapiloff, M.S., Piggott, L.A., Sadana, R., Li, J., Heredia, L., Henson, E., Efendiav, R. and Dessauer, C.W. An Adenylyl Cyclase-mAKAPβ Signaling Complex Regulates cAMP Levels in Cardiac Myocytes. Journal of Biological Chemistry, 284 (35):23540-23546, 2009. PMC2749128.
  • Li, J., Negro, A., Lopez, J., Bauman, A.L., Henson, E., Dodge-Kafka, K.L., and Kapiloff, M.S. The mAKAPβ Scaffold Regulates Cardiac Myocyte Hypertrophy via Recruitment of Activated Calcineurin, Journal of Molecular and Cellular Cardiology, 48: 387–394, 2010. PMC2813376.
  • Dodge-Kafka, K.L., Bauman, A., Mayer, N., Henson, E., Heredia, L., Ahn, J., McAvoy, T., Nairn, A. C., and Kapiloff, M.S. cAMP-Stimulated Protein Phosphatase 2A Activity Associated with mAKAP Signaling Complexes Inhibits the Phosphorylation and Activity of the cAMP-Specific Phosphodiesterase PDE4D3, Journal of Biological Chemistry, 285 (15):11078-11086, 2010. PMC2856983.
  • Zhang, L., Malik, S., Kelley, G.G., Kapiloff, M.S. and Smrcka, A.V. Phospholipase Cᵋ Scaffolds To Muscle-specific A Kinase Anchoring Protein (mAKAPβ) And Integrates Multiple Hypertrophic Stimuli In Cardiac Myocytes. Journal of Biological Chemistry, 286 (26): 23012–23021, 2011. PMC3123069
  • Vargas, M.A., Tirnauer, J.S., Glidden, N., Kapiloff, M.S., and Dodge-Kafka, K.L. Myocyte Enhancer Factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation. Cellular Signalling, 24 (8):1496-503, 2012. PMC3362667
  • Li, J., Vargas, M.A.X., Kapiloff, M.S.,* and Dodge-Kafka, K.L.* Regulation of MEF2 Transcriptional Activity by Calcineurin-mAKAP Complexes. Experimental Cell Research, 319 (4):447-454, 2013. PMC3563847 *co-corresponding authors
  • Rusconi, F., Thakur, H., Li, J., and Kapiloff, M.S. CIP4 is Required for the Hypertrophy of Neonatal Cardiac Myocytes in Vitro. Journal of Biomedical Science, 20 (1): 56, 2013. PMC3750294
  • Li, J., Kritzer, M.D., Carlisle Michel, J.J., Le, A., Thakur, H., Gayanilo, M., Passariello, C., Negro, A., Danial, J.B., Oskouei, B., Sanders, M., Hare, J.M., Hanauer, A., Dodge-Kafka, K.L., and Kapiloff, M.S. Anchored p90 Ribosomal S6 Kinase 3 is Required for Concentric Cardiac Myocyte Hypertrophy. Circulation Research, 112: 128-139, 2013. PMC3537852
  • Passariello, C., Gayanilo, M., Kritzer, M.D., Thakur, H., Cozacov, Z., Rusconi, F., Wieczorek, D., Sanders, M., Li, J., and Kapiloff, M.S. p90 Ribosomal S6 Kinase 3 is Required for Interstitial Fibrosis In α-tropomyosin Glu180Gly Transgenic Mice. American Journal of Physiology – Heart and Circulatory Physiology, 305 (7): H1010-H1019, 2013. PMC3798750 – Featured in a podcast: http://ajpheart.podbean.com/2013/10/03/p90-ribosomal-s6-kinase-3-and-interstitial-fibrosis
  • Kritzer, M.D., Li, J., Passariello, C., Gayanilo, M., Thakur, H., Dayan, J., Dodge-Kafka, K.L., and Kapiloff, M.S. The Scaffold Protein mAKAPᵝ Orchestrates Cardiac Myocyte Hypertrophic Signaling Required for the Development of Heart Failure. Circulation: Heart Failure, in press.

Review Articles

  • Diviani, D., Dodge-Kafka, K.L., Li, J., and Kapiloff, M.S. A-kinase Anchoring Proteins-Scaffolding Proteins in the Heart. American Journal of Physiology – Heart and Circulatory Physiology, 301: H1742-H1753, 2011. PMC3213966
  • Kritzer, M.D., Li, J., Dodge-Kafka, K.L., and Kapiloff, M.S. AKAPs: The Architectural Underpinnings of Local cAMP signaling. Journal of Molecular and Cellular Cardiology, 52 (2): 351-358, 2012. PMC3168680